SideroScanner¶
SideroScanner is a specialized tool for annotating TonB-dependent iron-regulated outer membrane proteins (IROMPs) and siderophore receptors in Gram-negative bacteria.
Iron-uptake receptors are critical entry portals for siderophore-cephalosporin conjugates such as cefiderocol, as well as key virulence factors in pathogens like Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa.
Highlights¶
- Targeted Receptor Profiling: Detects and classifies homologous siderophore receptors across diverse Gram-negative assemblies.
- Mutation & Truncation Screening: Helps link structural disruptions or frameshifts in iron transport pathways to reduced cefiderocol susceptibility.